6/21/2023 0 Comments Norco pain medConsider a reduction in dosage of clobazam if adverse reactions known to occur with clobazam are experienced when co-administered with EPIDIOLEX. This may increase the risk of clobazam-related adverse reactions. The prescribing information for Epidiolex, an FDA-approved prescription CBD product, states the following: Coadministration of EPIDIOLEX produces a 3-fold increase in plasma concentrations of N-desmethylclobazam, the active metabolite of clobazam (a substrate of CYP2C19). This increases the risk of adverse effects. This metabolite is further metabolized by CYP2C19, a major liver metabolizing enzyme.ĬBD is known to inhibit CYP2C19, which decreases how quickly N-desmethylclobazam is metabolized, leading to increased concentrations of it. Past the additive sedative effects, there doesn't seem to be a significant metabolic interaction.which is generally why most interactions occur.Īn example of a metabolic interaction is between the example I used above.for CBD and clobazam.Ĭlobazam is broken down in the body and produces an active metabolite (N-desmethylclobazam). You certainly want to see how they would affect you before performing any tasks that require mental alertness (like driving). CBD With Oxycodone And HydrocodoneĪt the outset, it is important to remember that taking CBD with either of these drugs could cause additive sedative effects since all three are associated with it. In fact, CBD products (and THC ones too) are commonly used medicinally as an adjunct or even alternative therapy for those taking opioids. There is less evidence that CBD interacts in a significant manner with either hydrocodone or oxycodone. Cannabidiol and Serum Antiepileptic Drug Levels: The ABCs of CBD With AEDs This study emphasizes the importance of monitoring serum AED levels and LFTs during treatment with CBD. Abnormal liver function test results were noted in participants taking concomitant valproate. One concluded the following: Significantly changed serum levels of clobazam, rufinamide, topiramate, zonisamide, and eslicarbazepine were seen. CBD InteractionsĮven though CBD is 'natural', that doesn't mean it is without its dangers or potential to affect other medications.įor example, recent studies have shown the CBD can significantly interact with several antiepileptic drugs, notably Onfi ( clobazam). In the next section, I discuss whether or not there is a potential drug interaction between hydrocodone (one of the active ingredients in Norco), oxycodone (the active ingredient in Oxycontin) and hemp (specifically CBD). How effective it is is still something that studies are trying to elucidate, but initial ones are promising. Most hemp-based products are being used for their CBD ( cannabidiol) content, which studies show have a range of potentially beneficial effects, especially when it comes to pain.įor the treatment of pain, CBD is most often used for inflammatory conditions, such as arthritis, joint pain and back pain. Hemp-based products have been exploding in popularity recently, and it certainly is a good idea to look into potential drug interactions before using them.
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